Genesis 26:35 KJV
Which were a grief of mind unto Isaac and to Rebekah.
Genesis 26:35, King James Version
In context
34 And Esau was forty years old when he took to wife Judith the daughter of Beeri the Hittite, and Bashemath the daughter of Elon the Hittite:
35 Which were a grief of mind unto Isaac and to Rebekah.